At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Within AbbVie’s Biotherapeutics and Genetic Medicine (BGM) organization, our siRNA team is advancing therapeutic programs from early discovery through development, applying rigorous biology and data-driven decision making to build differentiated RNA medicines.

AbbVie is seeking a Senior Scientist I with deep, hands-on expertise in siRNA therapeutic discovery to join the siRNA group within Biotherapeutics and Genetic Medicine (BGM). This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

This role is best suited for candidates with direct, hands-on experience in therapeutic siRNA discovery, where siRNA biology directly informed experimental and program-level decisions.

Responsibilities

• Independently lead in vitro siRNA discovery biology, including experimental strategy, assay design, execution, data analysis, and interpretation in support of active therapeutic programs.
• Design, optimize, and validate fit-for-purpose assays that directly inform siRNA potency, durability, specificity, and mechanism-of-action.
• Drive scientific decision making by integrating siRNA knockdown data with orthogonal readouts (protein, functional, and transcriptomic endpoints).
• Identify and resolve key biological and technical risks related to siRNA activity, delivery, and on-target effects.
• Work with cross-functional partners (chemistry, delivery, bioinformatics, in vivo biology) to advance siRNA candidates through discovery milestones.
• Maintain high experimental rigor and productivity while operating with minimal supervision.
• Author internal technical reports and contribute as a primary author on publications and/or inventor on patents.